College of Medicine

Medical Physiology
This course is conducted using lectures, clinical correlation lectures, case conferences, and assigned readings. Supplementary information is provided through audiovisual units that help illustrate various principles of normal human physiology. The course is divided into major topics beginning with cell physiology and followed by the cardiovascular system, pulmonary physiology, renal/acid-base physiology, gastrointestinal physiology and endocrinology.
Course Director: Dana Gaddy, Ph.D.

Medical Cell Biology
As professionals in the field of medicine, we are currently in a remarkable era of understanding molecular regulation of human physiology.  Key to this understanding are many recent advances in cellular and molecular biology, many of which will allow you as physicians to have an opportunity to practice medicine unlike any of your predecessors.  Another of the primary goals of MCB is to emphasize the relevance of basic science to the practice of medicine.  In addition to being integrated with MBioc, we will be introducing a Problem Based Learning (PBL) format in this course.  While administratively, the PBLs are housed in MCB, you will be examined on them in both MCB and MBioc.
Course Director: Robert E. McGehee, Ph.D.

Graduate School

PHYO 5110 Protein Crystallography and Protein Structure (I)
The goal of this course is to provide a basic knowledge for analyzing molecular structure using x-ray crystallographic techniques. The topics will include the general principles of x-ray diffraction, crystallization techniques and model building. The course is also intended to give the students an insight into structure-function relationships of biological molecules. Prerequisite:  consent of instructor.
Course Director: Kottayil I. Varughese, Ph.D.

PHYO 5103 General Physiology
This course is a lecture-based survey of mammalian organ systems physiology with emphasis on human physiology. Each of the major organ systems, cardiovascular, pulmonary, renal, and gastrointestinal, are covered along with cell physiology, endocrinology and neurophysiology.
Course Directors: Parimal Chowdhury, Ph.D. and Rosalia Simmen, Ph.D.

PHYO 5033 Cellular Endocrinology
This course covers general or vertebrate endocrinology, both anatomical and physiological, with lectures and laboratory exercises each week. In addition, students will prepare a term paper on a selected area in the field. Prerequisite: PHYO500V and consent.
Course Director: Dana Gaddy, Ph.D.

PHYO 5107 Molecular Biophysics I
Introduction to molecular biophysics: the investigation of the structure, dynamics and function of biological macromolecules, using physical techniques. Subject matter includes selected cellular macromolecules (e.g., polypeptides, nucleic acids), the role of molecular chaperones, and relevant topics in radiation biophysics. Prerequisites: BIOC 5103 or equivalent.
Course Director: William A. Nagle, Ph.D.

PHYO 5093 Cell Biology
The structure and function of cells and cellular organelles with particular attention to how these interact in larger units of organization. (Same as ANAT 5093 and BIOC 5093)
Course Director: Jason Chang, Ph.D.

PHYO 5112 Regulation of Gene Expression
The focus of this course will be on the various processes involved in the flow of information from genes to their expressed products. Regulation of these processes will be explored in depth for both prokaryotic and eukaryotic systems. Topics will include: genomic organization, DNA replication and recombination, transcription, RNA processing, translation, genomics and proteomics, differentiation and development. Prerequisite: consent of instructor.
Course Director: Patricia A. Wight, Ph.D.

PHYO 6103 Molecular Cell Biology
Lectures and discussion of relevant publications which cover major processes in cell biology. Classes will emphasize the molecular models and experimental data that describe these cell processes. Topics will include nuclear import/export, protein secretion and trafficking, endocytosis and excytosis, cell cycle control and signal transduction. Prerequisite: Prior course in cell biology or consent; course in biochemistry or molecular biology recommended. (Same as MBIM 6104)
Course Director: Vladimir Lupashin, Ph.D.