Graduate Molecular Cell Biology
Molecular Cell Biology – MBIM 6103
The goals of this course are to develop a better understanding of the molecular mechanisms underlying basic processes in cell biology. This will be achieved by discussing in depth experimental studies that lead to proposed mechanistic models. In addition, these studies will introduce you to potential experimental approaches to attack scientific questions. We encourage you to critically evaluate the experiments and to incorporate this information with that from your previous or ongoing courses and research activities.
Prerequisites: Prior course in cell biology or permission of instructor. Biochemistry / Gene Expression is recommended. The course will be taught with the assumption that you have had courses in these areas.
Course Director: Vladimir Lupashin, 501-603-1170
Karen Abbott (Winthrop P. Rockefeller Cancer Institute, Rm. 11-111, email@example.com)
Giulia Baldini (Biomedical Research Center B421F, GBaldini@uams.edu)
Paul Gottschall (Biomed 2-B341C-2, PEGottschall@uams.edu)
Thomas Kelly (Biomed 2, KellyThomasJ@uams.edu)
Vladimir Lupashin (Biomed 2 261-2, VVLupashin@uams.edu)
Angus MacNicol (Cancer Institute 310, Angus@uams.edu)
Brian Storrie (Biomed 2 262-2, StorrieBrian@uams.edu)
Course structure: The course will be 4 credit hours;
The course will be 4 credit hours; Class meetings: Tuesday from 10:30am-1:30pm and Friday from 9:30am—12:30pm in Biomed Two, Physiology Conference Room 242-2.
The course will be a combination of lectures, weekly written work or problem sets and class discussions.
Texts: There is no required text. Molecular Cell Biology by Lodish et al is one of several textbooks that can be used for background information. Virtually all of the assigned readings will be on specific papers germane to the topic being discussed.
Written assignments: For some of the sections, there will be problem sets. For other sections there will be written assignments.
1. In-Class Paper Discussions (30%)
2. Problem sets / written class assignments (30%)
3. Exams (20% – 1st, 20% – 2nd)
To logon to Blackboard:
- Go to https://uams.blackboard.com/
- Your Username and Password are the same as your UAMS Username and Password.
- After you log in, click on “GRAD MBIM 6103 Molecular Cell Biology Fall 2017“
- You will see links on the side of the page. Click on the “Content” link to access the PPTs.
General outline and topic organization: MCB 2015 Schedule
|Class Period||Faculty||Class Period||General Topics|
|Tue, Aug 18||Storrie||1||Course Organization / Introduction:|
|Fri, Aug 21||Storrie||2||Using Microscopy in Cell Biology|
|Tue, Aug 25||Storrie||3||Nuclear transport - structure of nuclear envelope / pores|
|Fri, Aug 28||Storrie||4||Getting things in and out: protein and RNA import/export;|
|Tue, Sept 1||Storrie||5||Organelle Assembly and Function - the Golgi Apparatus as the prototype example|
|Fri, Sept 4||No CLASS|
|Tue, Sept 8||Storrie||6||Organelle Assembly and Function - the Golgi Apparatus as the prototype example|
|Fri, Sept 11||Baldini||7||ER and ER stress|
|Tue, Sept 15||Baldini||8||G proteins and Signal Transduction|
|Fri, Sept 18||Baldini||9||integration of distinct signaling pathways|
|Tue, Sept 22||Lupashin||10||ER protein transport ? translocation and retro-translocation|
|Fri, Sept 25||Lupashin||11||Protein sorting and vesicle formation|
|Tue, Sept 29||Lupashin||12||Vesicular trafficking|
|Fri, Oct 2||Lupashin||13||SNARE-dependent membrane fusion|
|Tue, Oct 6||Lupashin||14||Toxin trafficking|
|Fri, Oct 9||Lupashin||15||Autophagy|
|Tue, Oct 13||Exam I||Take home exam - (Pick up on Tuesday, Return on Friday, 9AM)|
|Fri, Oct 16||No CLASS|
|Tue, Oct 20||Baldini, Lupashin, Storrie||17||Exam discussion|
|Fri, Oct 23||Abbott||18||Functional roles for glycoconjugates: lessons learned from human diseases and congenital disorders of glycosylation|
|Tue, Oct 27||19||Functional roles for glycoconjugates|
|Fri, Oct 30||20||Functional roles for glycoconjugates|
|Tue, Nov 3||Kelly||21||Cell Adhesion|
|Fri, Nov 6||22||Cytoskeleton|
|Tue, Nov 10||23||Cytoskeleton|
|Fri, Nov 13||Gottschall||24||Functional synaptic plasticity|
|Tue, Nov 17||25||Signaling and the cytoskeleton in structural synaptic plasticity|
|Fri, Nov 20||26||Extracellular microenvironment, synaptic plasticity and memory|
|Tue, Nov 24||Thanksgiving week no class|
|Fri, Nov 27||Thanksgiving week no class|
|Tue, Dec 1||Macnicol||27||Control Cell Cycle and Cell Division|
|Fri, Dec 4||28||Stem Cell Biology|
|Tue, Dec 8||29||TBD|
|Fri, Dec 11||Exam II||30||Take home exam (Pick up on Friday, Return on Monday 9 AM)|
|Tue, Dec 14||No CLASS|
|Fri, Dec 17||Abbott, Kelly, Gottschall, Macnicol||31||Exam discussion|