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Herschel Conaway

Herschel Conaway, Ph.D.
Associate Professor
Ph.D., University of Missouri
Office:(501) 686-5125
Fax: (501) 686-8167
ConawayHowardH@uams.edu

Dr. Conaway’s research is directed at defining physiological agents which stimulate osteoclasts and bone resorption. Recent studies have included a strong collaborative effort with Professor Ulf H. Lerner, Head, Department of Oral Cell Biology, University of Umea, Sweden.

Dr. Conaway taught in the UAMS Medical Physiology course for 42 years. During that time, he received three “Golden Apple Awards” from the freshman medical class designating him as an outstanding instructor in the freshmen year. In the new UAMS medical school curriculum instituted in 2013, Dr Conaway is the Basic Science Director of the Endocrine/Reproduction Module taught in the M2 year. Dr. Conaway also directs and teaches in senior medical student electives and has been presented with “Red Sash” awards on numerous occasions from graduating senior classes for his service. In addition, he has served as the course coordinator and lectures in the graduate school course, Cellular Endocrinology, as well as lectures in the graduate school course: General Physiology.

On two occasions, Dr. Conaway has served as an elected representative from the College of Medicine to the Academic Senate Council. Dr. Conaway has been the Director of Graduate Studies in the Department of Physiology and Biophysics. He also has served on the campus-wide Graduate School Committee and on the Graduate Student Research Funds Allocation Committee. In addition, Dr. Conaway has served on medical school promotions committees, as a member of the Research Council, in the Physician Educator Honors Program, as Chairman of the Animal Care and Use Committee at UAMS and as the Department of Physiology and Biophysics representative on the Medical School Curriculum Committee.

Representative Publications

Conaway HH, Henning P, Lerner UH. Vitamin A metabolism, action, and role in skeletal homeostasis. Endocr Rev. 2013 May 29. [Epub ahead of print]

Souza PP, Palmqvist P, Lundberg P, Lundgren I, Hänström L, Souza JA, Conaway HH, Lerner UH. Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts. Mol Immunol. 49:601-10, 2012.

Conaway HH, Pirhayati A, Persson E, Svensson O, Lindholm C, Henning P, Tuckerman J, Lerner UH. Retinoids stimulate periosteal bone resorption by enhancing RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem  286:31425-31436, 2011.

Conaway HH, Persson E, Hahlen M, Granholm S, Svensson O, Pettersson U, Lie A, Lerner UH. Retinoids inhibit differentiation of hematopoetic osteoclast precursors. FASEB J. 23: 3526-3538, 2009.

Swanson C, Lorentzon M, Conaway HH, Lerner UH. Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kB (NF-kB) ligand, osteoprotegerin, and receptor activator of NF-kB in mouse calvarial bones. Endocrinology 147:3613-3622, 2006.

Palmquist P, Lundberg P, Persson E, Anders J, Lundgren I, Lie A, Conaway HH, Lerner UH.   Inhibition of hormone and cytokine stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased OPG and decreased RANKL and RANK in a STAT6 dependent pathway. J Biol Chem 281:2414-2429, 2006

Schwab AM, Granholm S, Persson E, Wilkes B, Lerner UH, Conaway HH. Stimulation of resorption in cultured mouse calvarial bones by thiazolidinediones. Endocrinology 146:4349-4361, 2005.

Link to Dr. Conaway at PubMed