UAMS.EDU

Jerry Ware

Jerry Ware

Professor
Ph.D., University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab:  (501) 526-7528
jware@uams.edu  

Dr. Ware’s laboratory studies fundamental aspects of platelet biology to elucidate their role of in hemostasis, thrombosis and in the development of cardiovascular disease. Since platelets are anucleate fragments of cytoplasm, in vivo models are used based on the hypothesis that the unique cellular characteristics of megakaryocytes and platelets require the correct in vivo environment for meaningful assessment of biological properties. Currently, we are characterizing variants of the human glycoprotein Ib receptor expressed on the surface of circulating mouse platelets. Methodologies include the generation of transgenic and gene-targeted deletions in the mouse genome. These studies are defining the molecular mechanisms controlling normal platelet generation and the role of specific platelet receptors in disease.

Representative Publications

Yin, H., Stojanovic, A., Xu, W., Corken, A., Zakharov, A., Qian, F., Pavlovic, A., Krbanjevic, A., Lyubimov, A.V., Wang, Z.J., Ware, J., and Du, X.  2013  The role of platelet glycoprotein Ib-IX and effect of an inhibitor of GPIb-IX function in endotoxemia-induced microvascular thrombosis and thrombocytopenia.  Atheroscler Throm Vas Biol.  In Press.

Boulaftali, Y., Hess, P.R., Getz, T.M., Cholka, A., Stolla, M., Mackman, N., Owens, A.P., III, Ware, J., Kahn, M.L., and Bergmeier, W. 2013. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest 123:908-916.

Joglekar, M.V., Ware, J., Xu, J., Fitzgerald, M.E., and Gartner, T.K. 2013. Platelets, glycoprotein Ib-IX, and von Willebrand factor are required for FeCl3-induced occlusive thrombus formation in the inferior vena cava of mice. Platelets 24:205-212.

Hillgruber, C., Steingraber, A.K., Poppelmann, B., Denis, C.V., Ware, J., Vestweber, D., Nieswandt, B., Schneider, S.W., and Goerge, T. 2013. Blocking von Willebrand factor for treatment of cutaneous inflammation J Invest Dermatol [Epub adhead of print}

Ware, J., Corken, A., and Khetpal, R. 2013. Platelet function beyond hemostasis and thrombosis. Curr Opin Hematol 20:451-456.

Ware, J. 2013. Give me an intron: any intron. Blood 121:4251-4252.

Blood coverKanaji, T., Ware, J., Okamura, T., and Newman, P.J. 2012. GPIba regulates platelet size by controlling the subcellular localization of filamin. Blood 119:2906-2913. (Selected by Faculty of 1000 as top 2% of published articles in biology and medicine; see commentary in same issue) 

 

Jarvis, G.E., Bihan, D., Hamaia, S., Pugh, N., Ghevaert, C.J., Pearce, A.C., Hughes, C.E., Watson, S.P., Ware, J., Rudd, C.E. et al 2012. A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin alpha(2) beta(1). J Thromb Haemost 10:268-277.

Kanaji, S., Kuether, E.L., Fahs, S.A., Schroeder, J.A., Ware, J., Montgomery, R.R., and Shi, Q. 2012. Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy. Mol Ther 20:625-632.

von Bruhl, M.L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A., Tirniceriu, A., Coletti, R., Kollnberger, M. et al 2012. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 209:819-835.

Ziu, E., Mercado, C.P., Li, Y., Singh, P., Ahmed, B.A., Freyaldenhoven, S., Lensing, S., Ware, J., and Kilic, F. 2012. Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin. J Mol Cell Cardiol 52:1112-1121.

Ware, J. 2012. Fragmenting the platelet to reduce metastasis. Blood 120:2779-2780.

Ware, J., and Jain, S. 2012. Tumor growth and metastasis. In Platelets A.Michelson, editor. Elsevier. Amsterdam. 803-810.

Ware, J., and Suva, L.J. 2011. Platelets to hemostasis and beyond. Blood 117:3703-3704.

Boilard, E., Larabee, K., Shnayder, R., Jacobs, K., Farndale, R.W., Ware, J., and Lee, D.M. 2011. Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation. J Immunol 186:4361-4366.

Veeraputhiran, M., Ware, J., Dent, J., Bornhorst, J., Post, G., Cottler-Fox, M., Pesek, G., Theus, J., and Nakagawa, M. 2011. A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal. Transfusion 51:1030-1036.

Othman, M., Lopez, J.A., and Ware, J. 2011. Platelet-type von Willebrand disease update: the disease, the molecule and the animal model. Expert Rev Hematol 4:475-477.

Li, C., Piran, S., Chen, P., Lang, S., Zarpellon, A., Jin, J.W., Zhu, G., Reheman, A., van der Wal, D.E., Simpson, E.K. et al 2011. The maternal immune response to fetal platelet GPIba causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest 121:4537-4547.

Boilard, E., Nigrovic, P.A., Larabee, K., Watts, G.F., Coblyn, J.S., Weinblatt, M.E., Massarotti, E.M., Remold-O’Donnell, E., Farndale, R.W., Ware, J. et al 2010. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327:580-583.  (Selected by Faculty of 1000 as one of the top 5 biology reports of 2010; see commentary in the same issue) 

Jain, S., and Ware, J. 2010. The hemostasis/thrombosis paradigm in cancer. Hematology Education: the education program for the annual congress of the European Hematology Association 4:302-305.

Jain, S., Harris, J., and Ware, J. 2010. Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol 30:2362-2367.

Schmaier, A.A., Zou, Z., Kazlauskas, A., Emert-Sedlak, L., Fong, K.P., Neeves, K.B., Maloney, S.F., Diamond, S.L., Kunapuli, S.P., Ware, J., Brass, L.F., Smithgall, T.E., Saksela, K., and Kahn, M.L.  2009  Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.  Proc Natl Acad Sci USA, 106:21167-21172.

Blood CoverGuerrero, J.A., Kyei, M., Russell, S., Liu, J., Gartner, T.K., Storrie, B., and Ware, J.  2009  Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.  BLOOD, 114:5541-5546. (Cover Art for the same issue)

 

Fontana, G., Ware, J., and Cattaneo, M. 2009  Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis.  Haematologia, 94:581-584.

Jain, S., Russell, S., and Ware, J. 2009 Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. J Thromb Haemost. 7:1713-1717. (see Commentary in the same issue, pg 1712)

Suva, L.J., Hartman, E., Dilley, J.D., Russell, S., Akel, N.S., Skinner, R.A., Budde, U., Varughese, K.I., Kanaji, T. and Ware, J.  2008  Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathology, 172:430-439.

Cheli, Y., Jensen, D., Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J.A., Ware, J., Ruggeri, Z.M. and Kunicki, T.J.  2008  The Modifier of Hemostasis (MH) locus on mouse chromosome 4 controls in vivo hemostasis of Gp6-/- mice.  BLOOD, 111:1266-1273.

Guerrero, J.A., Shafirstein, G., Russell, S., Kanaji, T., Liu, J., Gartner, T.K., Baumler, W., Jarvis, G.E. and Ware, J.  2008 In vivo relevance for platelet glycoprotein Ibα Tyr276 in thrombus formation. J Thromb Haemost.,  6:684-691.

Liu, J., Joglekar, M., Ware, J., Fitzgerald, M.E.C., Lowell, C.A., Berndt, M.C., and Gartner, T.K.  2008 Evaluation of the physiological significance of botrocetin/von Willebrand factor in vitro signaling.  J Thromb Haemost.,  6:1915-1922.

Nishikii, H., Eto, K., Tamura, N., Hattori, K., Heissig, B., Kanaji, T., Sawaguchi, A., Goto, S., Ware, J. and Nakauchi, H.  2008  Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.  J Exp Medicine, 208:1917-1927. (see Commentary in same issue, pg 1717.

Link to Dr. Ware at PubMed