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Lawrence Cornett

Lawrence E. Cornett
Professor
Ph.D., University of California, Davis
Office: (501) 686-5441
Lab: (501) 686-7120
CornettLawrenceE@uams.edu

Dr. Cornett’s research interests are focused on regulation of adrenergic receptor gene expression in the rat lung and the homeostatic roles of the neurohypophysial hormone vasotocin in the domestic chicken. Adrenergic receptors mediate the effects of epinephrine and norepinephrine. My laboratory has developed adeno-associated viral vectors that express a functional β2-adrenergic receptor.  These vectors are being delivered to rat lung in order to increase β2-adrenergic receptor function in airway epithelial cells.  The long term goal is to increase sensitivity of the airways to the relaxing effects of β2-adrenergic agonists.  Regarding the actions of vasotocin, immunohistochemical techniques, radioimmunoassays and in situ hybridization histochemistry are being used to investigate regulation of vasotocin gene expression in the chicken hypothalamus under conditions of osmotic stress and during oviposition. We have cloned and pharmacologically characterized receptors that bind vasotocin and transduce its physiological effects in the shell gland and anterior pituitary gland.

In addition, Dr. Cornett is the Director of the Arkansas INBRE Program.  The goal of the Arkansas INBRE is to expand and strengthen the biomedical research infrastructure of academic institutions in the state by developing a multidisciplinary research network united by the scientific theme of Cellular Signaling, Growth, and Differentiation.

Dr. Cornett’s Laboratory Homepage

INBRE Web Site

Representative Publications

Srivastava R., L.E. Cornett, and C.M. Chaturvedi. Age-dependent expression of AVT and oxytocic-like receptor VT3 in the shell gland of Japanese quail, Coturnix coturnix japonica. General and Comparative Endocrinology 165:47-52, 2010.

Selvam R., A. Jurkevich, S.W. Kang, M.V. Mikhailova, L.E. Cornett, and W.J. Kuenzel. Distribution of the vasotocin subtype four receptor (VT4R) in the anterior pituitary gland of the chicken, Gallus gallus and its possible role in the avian stress response. Journal of Neuroendocrinology. 25:56-66, 2013.

Koryakina, Y., S.M. Jones, L.E. Cornett, K. Seely, L. Brents, P.L. Prather, A. Kofman, and R.C. Kurten. The effects of the -agonist isoproterenol on the down-regulation, functional responsiveness, and trafficking of 2-adrenergic receptors with amino-terminal polymorphisms. Cell Biology International. 36:1171-1183, 2013.

Cornett L.E., S.W Kang, and W.J. Kuenzel. A possible mechanism contributing to the synergistic action of vasotocin (VT) and corticotropin-releasing hormone (CRH) receptors on corticosterone release in birds. General and Comparative Endocrinology 188:46-53, 2013.

Srivastava R., L.E. Cornett, and C.M. Chaturvedi. Age-dependent expression of AVT and oxytocic-like receptor VT3 in the shell gland of Japanese quail, Coturnix coturnix japonica. General Comparative Endocrinology 165:47-52, 2010.

Sharma, D., L.E. Cornett, and C.M. Chaturvedi. Corticosterone- or metapyrone-induced alterations in adrenal function and expression of the arginine vasotocin VT2 in the pituitary gland of domestic fowl, Gallus gallus. General and Comparative Endocrinology 161:208-215, 2009.

Jurkevich, A., L.R. Berghman, L.E. Cornett, and W.J. Kuenzel. Immunohistochemical characterization of chicken pituitary cells containing the vasotocin VT2 receptor. Cell and Tissue Research 333:253-262, 2008.

Koriakina, Y., T.W. Fowler, S.M. Jones, B.J. Schnackenberg, L.E. Cornett, and R.C. Kurten. Characterization of a panel of six beta2-adrenergic receptor antibodies by indirect immunofluorescence microscopy. Respiratory Research 9:32, 2008.

Mikhailova, M.V., P. Mayeux, A. Jurkevich, W.J. Kuenzel, A. Periasamy, Y. Chen, and L.E. Cornett. Hetero-oligomerization between vasotocin and corticotrophin-releasing hormone (CRH) receptors augments CRH-stimulated cyclic AMP production. Molecular Endocrinology 21:2178-2188, 2007.

 

 

Link to Dr. Cornett at PubMed