Ph.D., McGill University
Office: (501) 686-5443; Cell: (501) 247-0312
Lab: (501) 686-5472
The overall goals of our laboratory are to study the mechanisms of disease processes such as smoking related pancreatic diseases and space travel related illness.
Over the years our research has focused on pulmonary physiology and gastrointestinal endocrinology as it relates to pathogenesis of pulmonary injury and induction of pancreatitis by smoke components. We have demonstrated that nicotine, one of the major and addictive components of cigarette smoking, is the most important agent in the trigger of inflammatory responses by pancreas resulting in alterations of pancreatic physiology that may lead to Pancreatitis and perhaps to Pancreatic Cancer development in smokers. The detailed mechanistic studies involve both in-vivo studies using rodents as animal species and in-vitro studies using immortalized and primary cell cultures. These studies are designed to determine mechanisms of nicotine-induced pathophysiological changes of the pancreas. In a separate collaborative project we are engaged in studies focused on an NASA validated animal model of simulated weightlessness representing microgravity, and study the effect of hind limb suspension to physiological responses in various tissues with an ultimate aim of developing countermeasures for space travel related sickness. Recently we have expanded our study with other team members from UAMS in studying the physiological alterations involving musculoskeletal, vascular and metabolic effects of microgravity and space radiation and their intimate connection to metabolic syndromes. We measure several physiological variables that include muscle disuse on oxidative processes, radiation, including nutrition and pressure-pain threshold in rodent model of simulated microgravity. We apply physiological, biochemical, ultra-structural and molecular techniques to conduct, collect and analyze the data.
Link to Dr. Chowdhury’s interview with the American Physiological Society in 2015
Grant support: 271-G1-50842-99; 216 G1-50395-01-02/04
Dr. Chowdhury’s Laboratory Homepage
Parimal Chowdhury. Simulated microgravity induced in rat via hindlimb unloading (HLS) induced modulation of tissue oxidative response when combined with calorie restriction. Arkansas Aerospace Proceedings Journal (accepted for publication, October 5, 2015)
Azida H Walker, Otis Perkins, Rahul Mehta, Nawab Ali, Maxim Dobretsov, Parimal Chowdhury.Changes in Mechanical properties of Rat Bones under simulated effects of Microgravity and Radiation. Physics Procedia 66: 610-616, 2015
Parimal Chowdhury, Ashley Long, Nisreen Akel, Dana Gaddy, Robert Griffin, Lauren Bailey and Maxim Dobretsov. Radiation combined with hind-limb suspension affects physiological parameters in rats. The FASEB JOURNAL vol 28 (1) Supplement 1103.7, April 2014
Parimal Chowdhury and John JayRoe. Effect of a natural polyphenol on nicotine-induced pancreatic cancer cell proliferation. Tobacco Induced Diseases 12 ( suppl):A7, 2014
P. Chowdhury, M. Soulsby, J. Pasley, D. McKay, and S. Bansal. Effects of dietary soy protein on hematological and Tissue Oxidant/Anti-oxidant levels in rats exposed to Simulated Microgravity. J Phys Chem and Biophys 3(1ssue 1):1-6, 2013
Parimal Chowdhury and Kodethoor B. Udupa. Effect of Nicotine on Exocytotic Pancreatic Secretory Response: Role of calcium signaling. Tobacco Induced Diseases 11:1-9, 2013 (Listed in Faculty of 1000 on February 20, 2013)
Parimal Chowdhury, Ashley Long, Gabriella Harris, Michael E. Soulsby, and Maxim Dobretsov. Animal model of simulated microgravity: a comparative study of hindlimb unloading via tail versus pelvic Suspension. Physiological Reports 1 (issue 1):1-11, 2013
Samar Hassen,Nawab Ali and Parimal Chowdhury. Molecular Signaling Mechanisms of Apoptosis in Hereditary Non-Polyposis Colorectal Cancer.World Journal Gastrointestinal Pathophysiology 2012, June 15 3(3):71-79.
Parimal Chowdhury and Stewart MacLeod. Smoking and Cancer. In: Cigarette Smoke Toxicity, Linking individual chemicals to human diseases. Bernhard, D.(Ed), Wiley Publishers, 2011 Wiley-VCH Verlag GmbH & Co.KGaA.Boschstr 12 69409, Weinheim, Germany, Chapter 8, pp 145-159. Published on line 24th Feb 2011; DOI 10 1002/9783527635320.ch8
Parimal Chowdhury; Michael E Soulsby; John J Jayroe; Akel S Nisreen; Dana Gaddy; Maxim Dobretsov,. Pressure Hyperalgesia in Hind-Limb Suspended Rats. Aviation Space Environ Med 82:988-991, 2011
Parimal Chowdhury. Parimal Chowdhury’s work on smoking related pancreatic disorders. World Journal Gastrointestinal Pathophysiology 2011 June 15; 2(3): 35-40