Jerry Ware, Ph.D.

Jerry Ware, Ph.D.

Professor
University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab:  (501) 526-7528
jware@uams.edu

Dr. Ware’s laboratory studies fundamental aspects of platelet biology to elucidate their role of in vascular disease. His interests in hematologic disorders began with a fellowship at the University of North Carolina, Chapel Hill.  From there, he spent the next 17 years at The Scripps Research Institute in La Jolla, CA.  He joined UAMS in 2004 as a Professor in the Department of Physiology & Biophysics.  Dr. Ware has published over 150 articles and reviews on many aspects of vascular biology but primarily focusing on hemostasis and thrombosis.  He has served as a grant reviewer for the National Institutes of Health for more than 30 years and is Co-director of the Hematology-Oncology module for freshman medical students.  His current research efforts focus on the interplay of inflammation, thrombosis, and cancer.

Representative Publications

Xu, M., Li, J., Miguel, N., Zhu, G., Carrim, N., Yu, R., Sahil, G., Marshall, J.C., Rotstein, O., Peng, J., Hou, M. Kunishim, S., Ware, J., Branch, D.R., Lazarus, A.H., Ruggeri, Z.M., Freedman, J., and H. Ni. 2018 GPIb is required for platelet-mediated hepatic thrombopoietin generation. Blood. In Press.

Ware, J. 2018 Let’s shear a moment, then take it inside. Blood. In Press.

Claushuis, T.A.M., de Stoppelaar, S.F., de Vos, A.F., Grootemaat, A.E., van der Wel, N.N., Roelofs, J., Ware, J., Van’t Veer, C., van der Poll, T. 2018 Nbeal2 deficiency increases organ damage but does not affect host defense during gran-negative pneumonia-derived sepsis. Arterioscler.Thromb.Vasc.Biol. [Epub ahead of print].

Stark, K., Schubert, I., Joshi, U., Kilani, B., Hoseinpour, P., Thakur, M., Grunauer, P., Pfeiler, S., Schmidergall, T., Stockhausen, S., Baumer, M., Chandraratne, S., von Bruhl, M.L., Lorenz, M., Colett, R., Reese, S., Laitinen, I., Wormann, S.M., Algul, H., Bruns, C.J., Ware, J., Mackman, N., Engelmann, B., and Massberg, S. 2018  Distinct pathogenesis of pancreatic cancer microvesicle-associated venous thrombosis identifies new antithrombotic targets in vivo. Arterioscler.Thromb.Vasc.Biol. 38:772-786.

Quach, M.E., Dragovich, M.A., Chen, W., Syed, A.K. Cao, W., Lang, X., Dent, W, De Meyer, S.F., Zhu, G., Peng, J., Ni, H., Bennett, C.M., Hou, M., Ware, J., Deckmyn, H., Zhang, X.F., and Li, R. 2018 Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets. Blood. 131:787-796.

Rayes, J., Jadoui, S., Lax, S., Gros, A., Wichaiyo, S., Ollivier, V., Denis, C.V., Ware, J., Nieswandt, B., Jandrot-Perrus, M., Watson, S.P., Ho-tin-Noe, B., 2017 The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent. Haematologica.  103:e256-e258.

Chen, W., Druzak, S.A., Wang, Y., Josephson, C.D., Hoffmeister, K.M., Ware, J., and Li, R.  2017 Refrigeration-induced binding of von Willebrand factor facilitates fast clearance of refrigerated platelets.  Arterioscler.Thromb.Vasc.Biol. 37:2271-2279.

Ware, J. and Post, S.R.  2017 Platelets and inflammatory disorders of connective tissue.  In: Platelets in thrombotic and non-thrombotic disorders. Chapter 78.  2nd Edition  Edited by P, Gresele, Lopez, J.A., Kleiman, N.S. C. Pgs 1133-1137, Cambridge University Press, Cambridge UK.

Cunin, P., Penke, L.R., Thon, J.N., Monach, P.A., Jones, Ta., Chang, M.H., Chen, M.M., Melki, I., Lacroix, S., Iwakura, Y., Ware, J., Gurish, M., Italiano, J., Boilard, E., and Nigrovic, P.A.  2017  Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis.  J. Clin. Invest. 127:1714-1724.

Dütting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, J.M., van Eeuwijk, M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., Heinz, N., Baig, A., Gorelashvili, M., Gerner, F., Heinze, K., Ware, J., Krohne, G., Ruggeri, Z., Nurden, A., Schulze, H., Modlich, U., Pleines, I., Brakebusch, C., and B. Nieswandt. 2017  A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Nature Comm. Jun 15;8:15838.

 Ware, J., and Varughese, K.I.  2017 Structural origins of hemostasis and adaptive immunity.  Res Pract Thromb Haemost. 1:286–290.

Kaur, H., Corscadden, K., Ware, J., and Othman, M.  2016  Thrombocytopathy leading to impaired in vivo hemostasis and thrombosis in platelet-type von Willebrand disease.  J. Thromb and Haemost.  117:543-555.

Liang, X., Syed, A., Russell, S. R., Ware J., and Li, R. 2016  Dimerization of glycoprotein Iba is not sufficient to induce platelet clearance.  J Thromb and Haemost.  14:381-386.

Chen, W., Liang, X., Syed, A., Jessup, P., Church, W. Ware, J., Josephson, C., and Li, R.  2016 Inhibiting GPIba shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage.  Arterioscler.Thromb.Vasc.Biol.  36:1821-1828.

Deng, W., Xu, Y., Chen, W., Paul, D.S., Syed, A.K., Dragovich, M.A., Liang, X., Zakas, P., Berndt, M.C., Di Paola, J., Ware, J., Lanza, F., Doering, C.B., Bergmeier, W., Zhang, X.F., and Li, R. 2016  Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.  Nature Comm.  Sept27, 2016.

Zhou, H., Ran, Y., Da, Q., Shaw, T.S., Shang, D., Reddy, A.K., Lopez, J.A., Ballantyne, C.M., Ware, J., Wu, H., and Peng, Y.  2016  Defective association of the platelet glycoprotein Ib-IX complex with the glycosphingolipid-enriched membrane domain inhibits murine thrombus and atheroma formation.  J. Immunol.  197:288-295.

Ware, J. 2016 A binding relationship with thrombin.  Blood.  127:525-526.

Ware, J. and Corken, A. 2015 Platelets.  In: Atherosclerosis: Risks, Mechanisms, and Therapies. Edited by Hong Wang and Cam Patterson. John Wiley & Sons Inc. Chapter 15. Pgs 187-195.

Franco, A.T., Corken A., and Ware, J.  2015. Platelets at the interface of thrombosis, inflammation, and cancer. Blood 126:582-588.

Nikolic, D.M., Vadali, S., He, B. et al. 2015. Prostaglandins produced during class A scavenger receptor-mediated macrophage adhesion differentially regulate cytokine production. J Leukoc Biol 97:901-908.

Chandraratne, S., von Bruehl, M.L., Pagel, J.I. et al. 2015 Critical role of platelet glycoprotein Ib(alpha) in arterial remodeling. Arterioscler Thromb Vasc Biol 2015:35:589-597.

 

Link to Dr. Ware at UAMS Profiles https://uams-triprofiles.uams.edu/profiles/display/127544