Jerry Ware, Ph.D.

Jerry Ware, Ph.D.

University of Arkansas for Medical Sciences
Office: (501) 526-6096
Lab:  (501) 526-7528


Dr. Ware’s laboratory studies fundamental aspects of platelet biology to elucidate their role of in hemostasis, thrombosis and in the development of cardiovascular disease. Since platelets are anucleate fragments of cytoplasm, in vivo models are used based on the hypothesis that the unique cellular characteristics of megakaryocytes and platelets require the correct in vivo environment for meaningful assessment of biological properties. Currently, we are characterizing variants of the human glycoprotein Ib receptor expressed on the surface of circulating mouse platelets. Methodologies include the generation of transgenic and gene-targeted deletions in the mouse genome. These studies are defining the molecular mechanisms controlling normal platelet generation and the role of specific platelet receptors in disease.

Representative Publications

Ware, J. and Post, S.R.  2017 Platelets and inflammatory disorders of connective tissue.  In: Platelets in thrombotic and non-thrombotic disorders. Chapter 78.  2nd Edition  Edited by P, Gresele, Lopez, J.A., Kleiman, N.S. C. Pgs 1133-1137, Cambridge University Press, Cambridge UK.

Kaur, H., Corscadden, K., Ware, J., and Othman, M.  2016  Thrombocytopathy leading to impaired in vivo hemostasis and thrombosis in platelet-type von Willebrand disease.  J. Thromb and Haemost.  117:543-555.

Cunin, P., Penke, L.R., Thon, J.N., Monach, P.A., Jones, Ta., Chang, M.H., Chen, M.M., Melki, I., Lacroix, S., Iwakura, Y., Ware, J., Gurish, M., Italiano, J., Boilard, E., and Nigrovic, P.A.  2017  Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis.  J. Clin. Invest. 127:1714-1724.

Dütting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, J.M., van Eeuwijk, M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., Heinz, N., Baig, A., Gorelashvili, M., Gerner, F., Heinze, K., Ware, J., Krohne, G., Ruggeri, Z., Nurden, A., Schulze, H., Modlich, U., Pleines, I., Brakebusch, C., and B. Nieswandt. 2017  A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Nature Comm. Jun 15;8:15838.

 Ware, J., and Varughese, K.I.  2017 Structural origins of hemostasis and adaptive immunity.  Res Pract Thromb Haemost. In Press.

Ware, J. and Post, S.R.  2016 Platelets and inflammatory disorders of connective tissue.  In: Platelets in thrombotic and non-thrombotic disorders. 2nd Edition  Edited by P, Gresele, Lopez, J.A., Kleiman, N.S. C. Page, Cambridge University Press, Cambridge UK. In Press.

Liang, X., Syed, A., Russell, S. R., Ware J., and Li, R. 2016  Dimerization of glycoprotein Iba is not sufficient to induce platelet clearance.  J Thromb and Haemost.  14:381-386.

Chen, W., Liang, X., Syed, A., Jessup, P., Church, W. Ware, J., Josephson, C., and Li, R.  2016 Inhibiting GPIba shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage.  Arterioscler.Thromb.Vasc.Biol.  36:1821-1828.

Deng, W., Xu, Y., Chen, W., Paul, D.S., Syed, A.K., Dragovich, M.A., Liang, X., Zakas, P., Berndt, M.C., Di Paola, J., Ware, J., Lanza, F., Doering, C.B., Bergmeier, W., Zhang, X.F., and Li, R. 2016  Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.  Nature Comm.  Sept27, 2016.

Zhou, H., Ran, Y., Da, Q., Shaw, T.S., Shang, D., Reddy, A.K., Lopez, J.A., Ballantyne, C.M., Ware, J., Wu, H., and Peng, Y.  2016  Defective association of the platelet glycoprotein Ib-IX complex with the glycosphingolipid-enriched membrane domain inhibits murine thrombus and atheroma formation.  J. Immunol.  197:288-295.

Ware, J. and Corken, A. 2015 Platelets.  In: Atherosclerosis: Risks, Mechanisms, and Therapies. Edited by Hong Wang and Cam Patterson. John Wiley & Sons Inc. Chapter 15. Pgs 187-195.

Ware, J. 2016 A binding relationship with thrombin.  Blood.  127:525-526.

Franco, A.T., Corken A., and Ware, J.  2015. Platelets at the interface of thrombosis, inflammation, and cancer. Blood 126:582-588.

Nikolic, D.M., Vadali, S., He, B. et al. 2015. Prostaglandins produced during class A scavenger receptor-mediated macrophage adhesion differentially regulate cytokine production. J Leukoc Biol 97:901-908.

Chandraratne, S., von Bruehl, M.L., Pagel, J.I. et al. 2015 Critical role of platelet glycoprotein Ib(alpha) in arterial remodeling. Arterioscler Thromb Vasc Biol 2015:35:589-597.

Corken, A., Russell, S., Dent J., Post, S.R., and Ware, J.  2014. Platelet glycoprotein Ib-IX as a regulator of systemic inflammation. Arterioscler Thromb Vasc Biol 2014:34:996-1001.

Pokidysheva, E., Boudko, S., Vranka, J. et al. 2014. Biological role of prolyl 3-hydroxylation in type IV collagen. Proc Natl Acad Sci U S A 2014:111:161-166.

Kanaji, S., Fahs, S.A., Ware, J., Montgomery, R.R., and Shi, Q 2014. Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard-Soulier syndrome
J Thromb Haemost 12:1726-1732.

Ware. J., and Post, S.R. 2014. Platelets: balancing the septic triad. Blood 124:3670-3672.

Hillgruber, C., Steingraber, A.K., Poppelmann, B., Denis, C.V., Ware, J., Vestweber, D., Nieswandt, B., Schneider, S.W., and Goerge, T. 2014. Blocking von Willebrand factor for treatment of cutaneous inflammation J Invest Dermatol 134:77-86.

Bynagari-Settipalli, Y.S., Cornelissen, I,, Palmer, D., et al.  2014. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol 34:2563-2569.

Yin, H., Stojanovic, A., Xu, W., Corken, A., Zakharov, A., Qian, F., Pavlovic, A., Krbanjevic, A., Lyubimov, A.V., Wang, Z.J., Ware, J., and Du, X.  2013  The role of platelet glycoprotein Ib-IX and effect of an inhibitor of GPIb-IX function in endotoxemia-induced microvascular thrombosis and thrombocytopenia.  Atheroscler Thromb Vasc Biol. 33:2529-2537.

Boulaftali, Y., Hess, P.R., Getz, T.M., Cholka, A., Stolla, M., Mackman, N., Owens, A.P., III, Ware, J., Kahn, M.L., and Bergmeier, W. 2013. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest 123:908-916.

Joglekar, M.V., Ware, J., Xu, J., Fitzgerald, M.E., and Gartner, T.K. 2013. Platelets, glycoprotein Ib-IX, and von Willebrand factor are required for FeCl3-induced occlusive thrombus formation in the inferior vena cava of mice. Platelets 24:205-212.

Ware, J., Corken, A., and Khetpal, R. 2013. Platelet function beyond hemostasis and thrombosis. Curr Opin Hematol 20:451-456.

Ware, J. 2013. Give me an intron: any intron. Blood 121:4251-4252.

Blood coverKanaji, T., Ware, J., Okamura, T., and Newman, P.J. 2012. GPIba regulates platelet size by controlling the subcellular localization of filamin. Blood 119:2906-2913. (Selected by Faculty of 1000 as top 2% of published articles in biology and medicine; see commentary in same issue) 


Jarvis, G.E., Bihan, D., Hamaia, S., Pugh, N., Ghevaert, C.J., Pearce, A.C., Hughes, C.E., Watson, S.P., Ware, J., Rudd, C.E. et al 2012. A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin alpha(2) beta(1). J Thromb Haemost 10:268-277.

Kanaji, S., Kuether, E.L., Fahs, S.A., Schroeder, J.A., Ware, J., Montgomery, R.R., and Shi, Q. 2012. Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy. Mol Ther 20:625-632.

von Bruhl, M.L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A., Tirniceriu, A., Coletti, R., Kollnberger, M. et al 2012. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 209:819-835.

Ziu, E., Mercado, C.P., Li, Y., Singh, P., Ahmed, B.A., Freyaldenhoven, S., Lensing, S., Ware, J., and Kilic, F. 2012. Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin. J Mol Cell Cardiol 52:1112-1121.

Ware, J. 2012. Fragmenting the platelet to reduce metastasis. Blood 120:2779-2780.

Ware, J., and Jain, S. 2012. Tumor growth and metastasis. In Platelets A.Michelson, editor. Elsevier. Amsterdam. 803-810.

Ware, J., and Suva, L.J. 2011. Platelets to hemostasis and beyond. Blood 117:3703-3704.

Boilard, E., Larabee, K., Shnayder, R., Jacobs, K., Farndale, R.W., Ware, J., and Lee, D.M. 2011. Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation. J Immunol 186:4361-4366.

Veeraputhiran, M., Ware, J., Dent, J., Bornhorst, J., Post, G., Cottler-Fox, M., Pesek, G., Theus, J., and Nakagawa, M. 2011. A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal. Transfusion 51:1030-1036.

Othman, M., Lopez, J.A., and Ware, J. 2011. Platelet-type von Willebrand disease update: the disease, the molecule and the animal model. Expert Rev Hematol 4:475-477.

Li, C., Piran, S., Chen, P., Lang, S., Zarpellon, A., Jin, J.W., Zhu, G., Reheman, A., van der Wal, D.E., Simpson, E.K. et al 2011. The maternal immune response to fetal platelet GPIba causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest 121:4537-4547.

Boilard, E., Nigrovic, P.A., Larabee, K., Watts, G.F., Coblyn, J.S., Weinblatt, M.E., Massarotti, E.M., Remold-O’Donnell, E., Farndale, R.W., Ware, J. et al 2010. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327:580-583.  (Selected by Faculty of 1000 as one of the top 5 biology reports of 2010; see commentary in the same issue) 

Jain, S., and Ware, J. 2010. The hemostasis/thrombosis paradigm in cancer. Hematology Education: the education program for the annual congress of the European Hematology Association 4:302-305.

Jain, S., Harris, J., and Ware, J. 2010. Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol 30:2362-2367.

Schmaier, A.A., Zou, Z., Kazlauskas, A., Emert-Sedlak, L., Fong, K.P., Neeves, K.B., Maloney, S.F., Diamond, S.L., Kunapuli, S.P., Ware, J., Brass, L.F., Smithgall, T.E., Saksela, K., and Kahn, M.L.  2009  Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.  Proc Natl Acad Sci USA, 106:21167-21172.

Blood CoverGuerrero, J.A., Kyei, M., Russell, S., Liu, J., Gartner, T.K., Storrie, B., and Ware, J.  2009  Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.  BLOOD, 114:5541-5546. (Cover Art for the same issue)


Fontana, G., Ware, J., and Cattaneo, M. 2009  Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis.  Haematologia, 94:581-584.

Jain, S., Russell, S., and Ware, J. 2009 Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. J Thromb Haemost. 7:1713-1717. (see Commentary in the same issue, pg 1712)


Link to Dr. Ware at PubMed