Michael L. Jennings, Ph.D.

Michael L. Jennings

Professor and Chair
Ph.D., Harvard University
Office: (501) 296-1438
Lab: (501) 296-1439
JenningsMichaelL@uams.edu

Walter Cannon wrote many decades ago that regulation is the central problem in physiology, and this remains true today.  The difference between Walter Cannon’s time and the present is that the identities of most of the molecular players in various cells are now known.  The challenge for the future is to understand how all these components interact to produce and regulate the living state.

The Department of Physiology and Biophysics has 14 primary faculty members and 14 faculty members with secondary appointments. Our faculty and students study physiological regulation at many different levels, including gene transcription, protein targeting, post-translational protein processing, subcellular signaling, extracellular matrix, control of differentiation and growth, and tumorigenesis.   The experimental systems used in the department include model organisms such as yeast; cultured mammalian cells; mouse models of human disease; and collaborative clinical trials in humans.  The physiological systems of interest to departmental faculty include skeletal, vascular, respiratory, gastrointestinal, central nervous, and endocrine.

Faculty research is supported by the NIH, NSF, USDA, NASA, American Cancer Society, American Heart Association, American Thyroid Association, and the National Multiple Sclerosis Society.  One of the largest federally funded programs at UAMS, the NIH IDeA Network of Biomedical Research Excellence (INBRE), is directed by Larry Cornett, a faculty member in our Department.

Education:  

UAMS recently reorganized the College of Medicine graduate programs into the “Graduate Program in Interdisciplinary Biomedical Sciences” (GPIBS), which includes six tracks.  Departmental faculty are affiliated with several GPIBS tracks, including the Cell Biology and Physiology track. For more information, see http://gradschool.uams.edu/gpibs/

Facilities:

The department is housed on the second floor of the Biomedical Research Center.  Within this space, individual laboratories and departmental shared facilities contain a wide variety of equipment needed for research in modern cellular and molecular biology.

An integrated fluorescence and electron microscopy core facility located on the first floor of the Biomedical Research Center is overseen by Dr. Brian Storrie (add link to Microscopy Core web site).  The facility houses a 200 KEV transmission electron microscope (FEI Technai G2 TF20), a Zeiss LSM 880 confocal microscope with Airyscan, and a Zeiss super-resolution microscope, and a new two-photon microscope.  In addition, a super-resolution holographic microscope is under construction, supported by an NIH U54 grant; Brian Storrie and Vladimir Lupashin are Co-PI’s of the grant with collaborators from Johns Hopkins University and Ben-Gurion University.

The physical facilities and collegial atmosphere in the department and across campus make the UAMS Department of Physiology and Biophysics an excellent place to pursue an academic career in biomedical science.  We invite you to meet our faculty and students by following the links on this page.

Representative Publications

Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. 2018. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem 293:9248-9264.

Ficici E, Faraldo-Gómez JD, Jennings ML, Forrest LR. 2017. Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism. J Gen Physiol 149: 1149-1164. (Article was featured in editorial comments.)

Myers EJ, Marshall A, Jennings ML, Parker MD. 2016. Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH conductance pathway that is stimulated by rises in intracellular and extracellular pH. Am J Physiol Cell Physiol 311: C945-C959.

Jennings M.L. 2013. Transport of hydrogen sulfide and hydrosulfide anion across the human red blood cell membrane. Rapid H2S diffusion and AE1-mediated Cl/HSexchange. Am J Physiol Cell Physiol 305: C941-C950.

Jennings M.L., Cui J. 2012. Inactivation of Saccharomyces cerevisiae sulfate transporter Sul2p: Use it and lose it. Biophys J 102: 768-776.

Link to Dr. Jennings at PubMed