Parimal Chowdhury, PhD

Professor
Ph.D., McGill University
Office: (501) 686-5443; Cell: (501) 247-0312
Lab: (501) 686-5472
ChowdhuryParimal@uams.edu

The overall goals of our laboratory are to study the mechanisms of disease processes such as smoking related pancreatic diseases and space travel related illness.
Over the years our research has focused on pulmonary physiology and gastrointestinal endocrinology as it relates to pathogenesis of pulmonary injury and induction of pancreatitis by smoke components. We have demonstrated that nicotine, one of the major and addictive components of cigarette smoking, is the most important agent in the trigger of inflammatory responses by pancreas resulting in alterations of pancreatic physiology that may lead to Pancreatitis and perhaps to Pancreatic Cancer development in smokers. The mechanistic studies proposed in this project involve 1) in-vivo studies using rodents as animal species and 2) in-vitro studies using immortalized differentiated mutant cell line and primary cell cultures. In separate collaborative projects with NASA, we apply NASA validated animal model of simulated weightlessness representing microgravity, and study the effect of hind limb suspension to physiological responses in various tissues with an ultimate aim of developing countermeasures for space travel related sickness. Recently we have expanded our study with other team members from UAMS to study the physiological alterations involving musculoskeletal, vascular and metabolic effects of microgravity and space radiation and their intimate connection to metabolic syndromes. Several physiological variables involving oxidative stress in muscle disuse, effect of radiation, nutritional deficiencies and pressure-pain threshold as a measure of insulin resistance are measured.

Link to Dr. Chowdhury’s interview with the American Physiological Society in 2015
http://www.the-aps.org/mm/Membership/Living-History/Chowdhury

Grant support: 271-G1-50842-99(RESERVE); 216 G1-50395-01-02/04 (ASGC); Gi-51157-01-02

Dr. Chowdhury’s Laboratory Homepage

Representative Publications

Parimal Chowdhury. Aminoguanidine (AG) induces pro-oxidant effect on AR42J cells, a Rat Pancreatic Tumor Cell line. Ann Clin & Lab Sci 47(5):217-225, 2017

Parimal Chowdhury, PhD, Nisreen Akel, BS, Azemat Jamshidi-Parsian, MS, Dana Gaddy, PhD, Robert J. Griffin, PhD, Jai Yadlapalli,PhD and Maxim Dobretsov, PhD. Degenerative tissue responses to space-like radiation doses in a rodent model of simulated microgravity. Ann Clin & Lab Sci, 46 (2): 87-94, 2016

Parimal Chowdhury. Simulated microgravity induced in rat via hindlimb unloading (HLS) induced modulation of tissue oxidative response when combined with calorie restriction. Arkansas Aerospace Proceedings, 2:21-25, 2016

Azida H Walker, Otis Perkins, Rahul  Mehta, Nawab  Ali, Maxim  Dobretsov, Parimal  Chowdhury.Changes in Mechanical properties of Rat Bones under simulated effects of Microgravity and Radiation. Physics Procedia 66: 610-616, 2015

Parimal Chowdhury, Ashley Long, Nisreen Akel, Dana Gaddy, Robert Griffin, Lauren Bailey and Maxim Dobretsov. Radiation combined with hind-limb suspension affects physiological parameters in rats. The FASEB JOURNAL vol 28 (1) Supplement 1103.7, April 2014

Parimal Chowdhury and John JayRoe. Effect of a natural polyphenol on nicotine-induced pancreatic  cancer cell proliferation. Tobacco Induced Diseases 12 ( suppl):A7, 2014

P. Chowdhury, M. Soulsby, J. Pasley, D. McKay, and S. Bansal. Effects of dietary soy protein on hematological and Tissue Oxidant/Anti-oxidant levels in rats exposed to Simulated Microgravity. J Phys Chem and Biophys 3(1ssue 1):1-6, 2013

Parimal Chowdhury and Kodethoor B. Udupa. Effect of Nicotine on Exocytotic Pancreatic Secretory Response: Role of calcium signaling. Tobacco Induced Diseases 11:1-9, 2013 (Listed in Faculty of 1000 on February 20, 2013)

Parimal Chowdhury, Ashley Long, Gabriella Harris, Michael E. Soulsby, and Maxim Dobretsov. Animal model of simulated microgravity: a comparative study of hindlimb unloading via tail versus pelvic Suspension. Physiological Reports 1 (issue 1):1-11, 2013

Samar Hassen,Nawab Ali and Parimal Chowdhury. Molecular Signaling Mechanisms of Apoptosis in Hereditary Non-Polyposis Colorectal Cancer.World Journal Gastrointestinal Pathophysiology 2012, June 15 3(3):71-79.

John Jayroe, Michael Soulsby and Parimal Chowdhury. Attenuation of tissue oxidative stress by dietary restriction in rats on simulated microgravity. Ann Clin & Lab Sci 42(2):301-305, 2012

Parimal Chowdhury and Stewart MacLeod.  Smoking and Cancer. In: Cigarette Smoke Toxicity, Linking individual chemicals to human diseases. Bernhard, D.(Ed), Wiley Publishers, 2011 Wiley-VCH Verlag GmbH & Co.KGaA.Boschstr 12 69409, Weinheim, Germany, Chapter 8, pp 145-159. Published on line 24th Feb 2011; DOI 10 1002/9783527635320.ch8

Parimal Chowdhury; Michael E Soulsby; John J Jayroe; Akel S Nisreen; Dana Gaddy; Maxim Dobretsov,. Pressure Hyperalgesia in Hind-Limb Suspended Rats. Aviation Space Environ Med 82:988-991, 2011

Parimal Chowdhury. Parimal Chowdhury’s work on smoking related pancreatic disorders. World Journal Gastrointestinal Pathophysiology 2011 June 15; 2(3): 35-40

Link to Dr. Chowdhury at PubMed